srt2104 capsules Search Results


srt2104  (MedChemExpress)
94
MedChemExpress srt2104
Srt2104, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/srt2104+capsules/SRT+2104/pm30030567-51-38-46
Average 94 stars, based on 1 article reviews
srt2104 - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
srt2104 capsules  (Sirtris Inc)
90
Sirtris Inc srt2104 capsules
Interaction of <t>SRT2104</t> with SIRT1. ( A ) Detailed binding profile of SRT2104 to SIRT1. ( B ) Illustrative representation of the molecular interaction between SRT2104 and SIRT1. Molecular docking simulations were conducted utilizing AutoDock software to model the interaction. A grid box measuring 126 Å in each dimension was established, with a grid point spacing of 0.375 Å. During the simulations, the ligands were allowed to flex, whereas the protein's amino acid residues were held fixed. The calculated binding energy served as a measure of affinity. Visualization of the interaction was enhanced using PyMol and Discover Studio, revealing that SRT2104 occupies the hydrophobic pocket of SIRT1. The amine group of SRT2104 forms hydrogen bonds with Gly269, Gln320, and Glu512 in the SIRT1 structure. Additionally, an oxygen atom of SRT2104 engages in a hydrogen bond with ARG282, contributing to the stability of the interaction. Hydrophobic contacts are further augmented by interactions between SRT2104 and SIRT1's Pro271, Arg282, Phe312, Lys314, and Phe321, including Pi-Pi stacking and alkyl interactions. Van der Waals forces involving Ile270, Ile279, Leu283, Ile316, Phe388, Ile510, and Thr511 also play a vital role in sustaining the interaction's stability.
Srt2104 Capsules, supplied by Sirtris Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/srt2104+capsules/srt2104/pmc10917792-15-27-46
Average 90 stars, based on 1 article reviews
srt2104 capsules - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

Image Search Results


Interaction of SRT2104 with SIRT1. ( A ) Detailed binding profile of SRT2104 to SIRT1. ( B ) Illustrative representation of the molecular interaction between SRT2104 and SIRT1. Molecular docking simulations were conducted utilizing AutoDock software to model the interaction. A grid box measuring 126 Å in each dimension was established, with a grid point spacing of 0.375 Å. During the simulations, the ligands were allowed to flex, whereas the protein's amino acid residues were held fixed. The calculated binding energy served as a measure of affinity. Visualization of the interaction was enhanced using PyMol and Discover Studio, revealing that SRT2104 occupies the hydrophobic pocket of SIRT1. The amine group of SRT2104 forms hydrogen bonds with Gly269, Gln320, and Glu512 in the SIRT1 structure. Additionally, an oxygen atom of SRT2104 engages in a hydrogen bond with ARG282, contributing to the stability of the interaction. Hydrophobic contacts are further augmented by interactions between SRT2104 and SIRT1's Pro271, Arg282, Phe312, Lys314, and Phe321, including Pi-Pi stacking and alkyl interactions. Van der Waals forces involving Ile270, Ile279, Leu283, Ile316, Phe388, Ile510, and Thr511 also play a vital role in sustaining the interaction's stability.

Journal: Scientific Reports

Article Title: Emerging roles of SIRT1 activator, SRT2104, in disease treatment

doi: 10.1038/s41598-024-55923-8

Figure Lengend Snippet: Interaction of SRT2104 with SIRT1. ( A ) Detailed binding profile of SRT2104 to SIRT1. ( B ) Illustrative representation of the molecular interaction between SRT2104 and SIRT1. Molecular docking simulations were conducted utilizing AutoDock software to model the interaction. A grid box measuring 126 Å in each dimension was established, with a grid point spacing of 0.375 Å. During the simulations, the ligands were allowed to flex, whereas the protein's amino acid residues were held fixed. The calculated binding energy served as a measure of affinity. Visualization of the interaction was enhanced using PyMol and Discover Studio, revealing that SRT2104 occupies the hydrophobic pocket of SIRT1. The amine group of SRT2104 forms hydrogen bonds with Gly269, Gln320, and Glu512 in the SIRT1 structure. Additionally, an oxygen atom of SRT2104 engages in a hydrogen bond with ARG282, contributing to the stability of the interaction. Hydrophobic contacts are further augmented by interactions between SRT2104 and SIRT1's Pro271, Arg282, Phe312, Lys314, and Phe321, including Pi-Pi stacking and alkyl interactions. Van der Waals forces involving Ile270, Ile279, Leu283, Ile316, Phe388, Ile510, and Thr511 also play a vital role in sustaining the interaction's stability.

Article Snippet: EUCTR2009-016537-98-DE , II , 80 , Type 2 Diabetes Mellitus between 18 and 65 years of age , Study to Assess the Safety, Tolerability and Activity of Oral SRT2104 Capsules Administered for 28 days to Subjects with Type 2 Diabetes Mellitus , 2010-03-03 to 2010-12-25 , Sirtris Pharmaceuticals Inc , Germany.

Techniques: Binding Assay, Software

Clinical trials involving SRT2104.

Journal: Scientific Reports

Article Title: Emerging roles of SIRT1 activator, SRT2104, in disease treatment

doi: 10.1038/s41598-024-55923-8

Figure Lengend Snippet: Clinical trials involving SRT2104.

Article Snippet: EUCTR2009-016537-98-DE , II , 80 , Type 2 Diabetes Mellitus between 18 and 65 years of age , Study to Assess the Safety, Tolerability and Activity of Oral SRT2104 Capsules Administered for 28 days to Subjects with Type 2 Diabetes Mellitus , 2010-03-03 to 2010-12-25 , Sirtris Pharmaceuticals Inc , Germany.

Techniques: Clinical Proteomics, Activity Assay, Capsules, Drug discovery, Suspension, Formulation

Schematic representation of the molecular mechanisms mediated by SRT2104. SRT2104, through the activation of SIRT1, orchestrates a network of molecular pathways, including P53, STAT3, ZKSCANS, AMPK, GR, GSK3β/PTEN, NF-κB, β-catenin/Runx2, MAPK, Smad7, FOXO, and TORC1. These interactions collectively contribute to the amelioration of conditions such as lung injury, diabetic vascular complications, diabetic nephropathy, cognitive impairments associated with diabetes, musculoskeletal disorders, brain ischemia–reperfusion injury, Parkinson's disease (PD) neurodegeneration, and optic nerve damage. Key:

Journal: Scientific Reports

Article Title: Emerging roles of SIRT1 activator, SRT2104, in disease treatment

doi: 10.1038/s41598-024-55923-8

Figure Lengend Snippet: Schematic representation of the molecular mechanisms mediated by SRT2104. SRT2104, through the activation of SIRT1, orchestrates a network of molecular pathways, including P53, STAT3, ZKSCANS, AMPK, GR, GSK3β/PTEN, NF-κB, β-catenin/Runx2, MAPK, Smad7, FOXO, and TORC1. These interactions collectively contribute to the amelioration of conditions such as lung injury, diabetic vascular complications, diabetic nephropathy, cognitive impairments associated with diabetes, musculoskeletal disorders, brain ischemia–reperfusion injury, Parkinson's disease (PD) neurodegeneration, and optic nerve damage. Key: "→" denotes activation or promotion, "⊥" indicates inhibition, "red arrow up" signifies upregulation, "green arrow down" signifies downregulation, and "Ac" refers to deacetylation.

Article Snippet: EUCTR2009-016537-98-DE , II , 80 , Type 2 Diabetes Mellitus between 18 and 65 years of age , Study to Assess the Safety, Tolerability and Activity of Oral SRT2104 Capsules Administered for 28 days to Subjects with Type 2 Diabetes Mellitus , 2010-03-03 to 2010-12-25 , Sirtris Pharmaceuticals Inc , Germany.

Techniques: Activation Assay, Inhibition

Overview of the potential effects of SRT2104 on various organ systems. The diagram illustrates the compound's impact on key physiological processes across different tissues. “↓”denotes a decrease or impairment, while “↑” signifies an increase or enhancement. This figure summarizes the multifaceted pharmacological actions of SRT2104, suggesting its potential therapeutic applications.

Journal: Scientific Reports

Article Title: Emerging roles of SIRT1 activator, SRT2104, in disease treatment

doi: 10.1038/s41598-024-55923-8

Figure Lengend Snippet: Overview of the potential effects of SRT2104 on various organ systems. The diagram illustrates the compound's impact on key physiological processes across different tissues. “↓”denotes a decrease or impairment, while “↑” signifies an increase or enhancement. This figure summarizes the multifaceted pharmacological actions of SRT2104, suggesting its potential therapeutic applications.

Article Snippet: EUCTR2009-016537-98-DE , II , 80 , Type 2 Diabetes Mellitus between 18 and 65 years of age , Study to Assess the Safety, Tolerability and Activity of Oral SRT2104 Capsules Administered for 28 days to Subjects with Type 2 Diabetes Mellitus , 2010-03-03 to 2010-12-25 , Sirtris Pharmaceuticals Inc , Germany.

Techniques: